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Investigating causal pathways in severe falciparum malaria: A pooled retrospective analysis of clinical studies.

Stije J LeopoldJames A WatsonAtthanee JeeyapantJulie Anne SimpsonNguyen H PhuTran T HienNicholas Philip John DayArjen M DondorpNicholas J White
Published in: PLoS medicine (2019)
These data suggest that moderate anaemia is associated with a reduced risk of death in severe falciparum malaria. This is possibly a direct causal association. The severe anaemia threshold criteria for a definition of severe falciparum malaria should be reconsidered.
Keyphrases
  • early onset
  • plasmodium falciparum
  • randomized controlled trial
  • electronic health record
  • study protocol