Role of Conserved Histidine and Serine in the HCXXXXXRS Motif of Human Dual-Specificity Phosphatase 5.
Ankan GuptaJaladhi BrahmbhattRaulia SyrlybaevaCatherine BodnarNatalia BodnarRobert BongardPhani Raj PokkuluriDaniel S SemRamani RamchandranRajendra RathoreMarat R TalipovPublished in: Journal of chemical information and modeling (2019)
Our molecular modeling and biochemical studies combined demonstrate that enzymatic activity of phosphatases can be manipulated by mutating specific conserved amino acid residues in the catalytic site (phosphatase domain). This strategy could facilitate generation of small molecules that will serve as agonists/antagonists of DUSP5 activity.