Evaluation of programmed cell death ligand 1 expression in a contemporary cohort of penile squamous cell carcinoma and its correlation with clinicopathologic and survival parameters: A study of 134 patients.
Anandi LoboSourav K MishraShilpy JhaAnkit TiwariRahul KapoorShivani SharmaSeema KaushalN Sri KiranmaiM Rakshitha DasKamal P PeddintiShailendra K SharmaNitin BhardwajSamriti AroraDeepika JainEkta JainGauri MunjalSayali ShindeVipra MalikHena SinghJuhi VarshneyDinesh PradhanMallika DixitNiharika PattnaikAshish K SharmaYogesh R BarapatreManas PradhanKaliprasad SatapathyDebadarshi RathSunil JaiswalStithi DasChiraranjan KhadengaSudhasmita RoutaManas R BaisakhRomila TiwariNakul Y SampatIndranil ChakrabartiAnil V ParwaniSambit Kumar MohantyPublished in: American journal of clinical pathology (2023)
Overall, PD-L1 expression is associated with high-grade and metastatic tumors. Lower PD-L1 expression is observed more frequently in HPV-associated (warty or basaloid) subtypes than in other, predominantly HPV-independent types. As a result, PD-L1 positivity, including higher expression, portends lower overall and cancer-specific survival. These data provide a rational for further investigating PD-L1-based immunotherapeutics in PC.