Pilot Evaluation of S-(3-[ 18 F]Fluoropropyl)-D-Homocysteine and O-(2-[ 18 F]Fluoroethyl)-D-Tyrosine as Bacteria-Specific Radiotracers for PET Imaging of Infection.

Helen M Betts Jeni C Luckett Philip J Hill

Published in: Molecular imaging and biology (2024)

F]FPHCys uptake was higher in infected tissues than inflammation, and represents a fluorine-18 labelled D-AA with potential to detect a S. aureus reference strain (Xen29) in vivo. Additional studies are needed to evaluate uptake of this radiotracer in clinical isolates.

Keyphrases

pet imaging
positron emission tomography
oxidative stress
gene expression
computed tomography
study protocol
case control
randomized controlled trial