Functional Role of microRNAs in Regulating Cardiomyocyte Death.
Urna KansakarFahimeh VarzidehPasquale MoneStanislovas S JankauskasJoseph H TaubePublished in: Cells (2022)
microRNAs (miRNA, miRs) play crucial roles in cardiovascular disease regulating numerous processes, including inflammation, cell proliferation, angiogenesis, and cell death. Herein, we present an updated and comprehensive overview of the functional involvement of miRs in the regulation of cardiomyocyte death, a central event in acute myocardial infarction, ischemia/reperfusion, and heart failure. Specifically, in this systematic review we are focusing on necrosis, apoptosis, and autophagy.
Keyphrases
- cell death
- systematic review
- oxidative stress
- acute myocardial infarction
- cell cycle arrest
- heart failure
- cardiovascular disease
- cell proliferation
- endoplasmic reticulum stress
- left ventricular
- angiotensin ii
- meta analyses
- endothelial cells
- cell cycle
- percutaneous coronary intervention
- vascular endothelial growth factor
- randomized controlled trial
- acute coronary syndrome
- metabolic syndrome
- coronary artery disease
- cardiovascular events