Brain Α-Tocopherol Concentration is Inversely Associated with Neurofibrillary Tangle Counts in Brain Regions Affected in Earlier Braak Stages: A Cross-Sectional Finding in the Oldest Old.
J TanprasertsukT M ScottM A JohnsonL W PoonP T NelsonA DaveyJ L WoodardR VishwanathanA K BarbeyK BargerX-D WangE J JohnsonPublished in: JAR life (2021)
Higher brain α-tocopherol level is specifically associated with lower NFT counts in brain structures affected in earlier Braak stages. Our findings emphasize the possible importance of α-tocopherol intervention timing in tauopathy progression and warrant future clinical trials.