Pillar[5]arene-based supramolecular photosensitizer for enhanced hypoxic-tumor therapeutic effectiveness.

Shuang ChaoZiyan ShenYuxin PeiYinghua LvXiaolin ChenJiaming RenKe YangZhichao Pei

Published in: Chemical communications (Cambridge, England) (2021)

A galactose-targeting supramolecular photosensitizer system DOX@GP5⊃NBSPD was constructed based on a host-guest inclusion complex. The supramolecular system could achieve efficient delivery of DOX/NBS and selective release under GSH stimulation. In vitro studies revealed that this supramolecular DOX/NBS co-delivery system exhibited high ROS production and excellent cancer cell damage capability in a hypoxic environment. This strategy can therefore achieve enhanced hypoxic-tumor therapeutic effectiveness by chemo-photodynamic combination.

Keyphrases

water soluble
photodynamic therapy
energy transfer
cancer therapy
randomized controlled trial
systematic review
oxidative stress
dna damage
wastewater treatment
single cell
squamous cell carcinoma
drug delivery
reactive oxygen species
quantum dots
locally advanced