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The Drugs of Sleeping Sickness: Their Mechanisms of Action and Resistance, and a Brief History.

Harry P de Koning
Published in: Tropical medicine and infectious disease (2020)
With the incidence of sleeping sickness in decline and genuine progress being made towards the WHO goal of eliminating sleeping sickness as a major public health concern, this is a good moment to evaluate the drugs that 'got the job done': their development, their limitations and the resistance that the parasites developed against them. This retrospective looks back on the remarkable story of chemotherapy against trypanosomiasis, a story that goes back to the very origins and conception of chemotherapy in the first years of the 20 century and is still not finished today.
Keyphrases
  • public health
  • locally advanced
  • risk factors
  • cross sectional
  • squamous cell carcinoma
  • rectal cancer
  • plasmodium falciparum