Development of a compact bidirectional promoter-driven dual chimeric antigen receptor (CAR) construct targeting CD19 and CD20 in the Sleeping Beauty (SB) transposon system.

Asmita KhaniyaS M Ali Hossieni RadJosh HalpinSupannikar TawinwungAlexander McLellanKoramit SuppipatNattiya Hirankarn

Published in: Journal for immunotherapy of cancer (2024)

The use of bidirectional promoters in a single vector offers advantages of size and robust CAR expression with the potential to expand use in other forms of gene therapies like CAR T cells.

Keyphrases

poor prognosis
dna methylation
nk cells
transcription factor
genome wide
gene expression
copy number
cancer therapy
human health
risk assessment
binding protein