Preclinical Modeling of Surgery and Steroid Therapy for Glioblastoma Reveals Changes in Immunophenotype that are Associated with Tumor Growth and Outcome.

Balint OtvosTyler J AlbanMatthew M Grabowski Defne BayikErin E Mulkearns-HubertTomas RadivoyevitchAnja RabljenovicSarah JohnsonCharlie AndrojnaAlireza M Mohammadi Gene H BarnettManmeet S AhluwaliaMichael A VogelbaumPeter E FecciJustin D Lathia

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

These data reveal that prior to intervention, increased tumor volume corresponds with reduced systemic immune function and that peripheral lymphocyte counts are prognostic when steroid treatment is taken into account.

Keyphrases

randomized controlled trial
minimally invasive
peripheral blood
coronary artery bypass
electronic health record
big data
stem cells
gene expression
machine learning
acute coronary syndrome
chemotherapy induced