Cancer-specific CTCF binding facilitates oncogenic transcriptional dysregulation.

Celestia FangZhenjia WangCuijuan HanStephanie L SafgrenKathryn A HelminEmmalee R AdelmanValentina SerafinGiuseppe BassoKyle P EagenAlexandre Gaspar-MaiaMaria E FigueroaBenjamin D SingerAakrosh RatanPanagiotis NtziachristosChongzhi Zang

Published in: Genome biology (2020)

Specific CTCF binding events occur in human cancers. Cancer-specific CTCF binding can be induced by other transcription factors to regulate oncogenic gene expression. Our results substantiate CTCF binding alteration as a functional epigenomic signature of cancer.

Keyphrases

papillary thyroid
gene expression
transcription factor
squamous cell
dna binding
endothelial cells
binding protein
dna methylation
lymph node metastasis
squamous cell carcinoma
oxidative stress