The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα.

Yumeng MiaoChangliu ZhangLing YangXi ZengYuxiao HuXinru XueYue DaiZhi-Feng Wei

Published in: Cell communication and signaling : CCS (2022)

The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα, which is beneficial for inflammatory and autoimmune diseases. Video Abstract.

Keyphrases

fatty acid
hydrogen peroxide
insulin resistance
oxidative stress
nk cells