Targeted next-generation sequencing of adult gliomas for retrospective prognostic evaluation and up-front diagnostics.

Jeanette K PetersenH B BoldtMia Dahl SørensenS BlachRikke Hedegaard DahlrotS HansenM BurtonM ThomassenT KruseF R PoulsenL AndreasenH HagerB P UlhøiS LukacovaG ReifenbergerBjarne Winther Kristensen

Published in: Neuropathology and applied neurobiology (2020)

Gene panel NGS proved feasible in daily diagnostics. In addition, our study confirms the prognostic role of glioma classification according to WHO 2016 in a large population-based cohort. Molecular features of glioblastoma in IDH-wildtype diffuse glioma were linked to poor survival corresponding to IDH-wildtype glioblastoma patients. The distinction between WHO grade II and III retained prognostic significance in patients with IDH-mutant diffuse astrocytic gliomas.

Keyphrases

low grade
high grade
wild type
end stage renal disease
copy number
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
physical activity
deep learning
cross sectional
young adults
patient reported outcomes
cancer therapy
single molecule
circulating tumor cells
childhood cancer