PKM2-dependent glycolysis promotes skeletal muscle cell pyroptosis by activating the NLRP3 inflammasome in dermatomyositis/polymyositis.

Di LiuYizhi XiaoBin ZhouSiming GaoLiya LiLijuan ZhaoWeilin ChenBingying DaiQiuxiang LiHuiqian DuanXiaoxia ZuoHui LuoHonglin Zhu

Published in: Rheumatology (Oxford, England) (2021)

Our study revealed upregulated glycolysis in the lesioned muscle tissues of DM/PM, which activated the NLRP3 inflammasome and leaded to pyroptosis in muscle cells. The levels of PKM2 and IL-1β were high in patients with anti-signal recognition particle autoantibody expression. These proteins might be used as new biomarkers for muscle damage.

Keyphrases

nlrp inflammasome
skeletal muscle
insulin resistance
single cell
interstitial lung disease
induced apoptosis
poor prognosis
signaling pathway
gene expression
oxidative stress
particulate matter
cell therapy
air pollution
heavy metals
risk assessment
disease activity
bone marrow