Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications.
J HanA SchmidtT ZhangH PermentierG M M GroothuisR BischoffFritz E KühnP HorvatovichAngela CasiniPublished in: Chemical communications (Cambridge, England) (2018)
Supramolecular Pd2L4 cages (L = ligand) hold promise as drug delivery systems. With the idea of achieving targeted delivery of the metallacages to tumor cells, the bioconjugation of exo-functionalized self-assembled Pd2L4 cages to peptides following two different approaches is reported for the first time. The obtained bioconjugates were analyzed and identified by high-resolution mass spectrometry.
Keyphrases
- high resolution mass spectrometry
- drug delivery
- liquid chromatography
- quantum dots
- ultra high performance liquid chromatography
- energy transfer
- gas chromatography
- molecularly imprinted
- amino acid
- water soluble
- mass spectrometry
- cancer therapy
- big data
- machine learning
- gold nanoparticles
- high resolution
- artificial intelligence
- ms ms