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Association between Single Nucleotide Polymorphisms and Glioma Risk: A Systematic Literature Review.

Cleciton Braga TavaresFrancisca das Chagas Sheyla Almeida Gomes-BragaEmerson Brandao SousaJosé Nazareno Pearce de Oliveira BritoMariella de Almeida MeloViriato CampeloFidelis Manes NetoRicardo Marques Lopes de AraújoIruena Moraes KesslerLeonardo de Moura Sousa JúniorLuís Carlos Carvalho FilhoYousef Qathaf AguiarPedro Vitor Lopes CostaBenedito Borges da Silva
Published in: Cancer investigation (2020)
This study aimed to determine the main single nucleotide polymorphisms (SNPs) that are associated with an increased or decreased risk of glioma development in healthy individuals. We conducted a systematic review of the articles published in English on the PUBMED database between January 2008 and December 2017. Our search resulted in a total of 743 articles; however, only 56 were included in this review. A total of 148 polymorphisms were found, which involved 64 different genes. The polymorphisms that were most associated with an increased risk of glioma development were polymorphic variants rs179782, rs13181, and rs3791679 of the genes XRCC1, ERCC2, and EFEMP1, respectively.
Keyphrases
  • genome wide
  • dna repair
  • copy number
  • genome wide identification
  • dna methylation
  • emergency department
  • randomized controlled trial
  • gene expression
  • adverse drug