TLR2 Supports γδ T cell IL-17A Response to ocular surface commensals by Metabolic Reprogramming.
Wenjie ZhuXiaoyan XuVijayaraj NagarajanJing GuoZixuan PengAmy ZhangJie LiuMary J MattapallilYingyos JittayasothornReiko HoraiAnthony J St LegerRachel R CaspiPublished in: bioRxiv : the preprint server for biology (2024)
(1) TLR2-deficient mice exhibit reduced γδ T cell responses to ocular commensal bacteria.(2) γδ T cell-intrinsic TLR2 deficiency causes defects of fatty acid oxidation and IL-17A production in a γδ subset-specific manner.(3) The transcription factor, IκBζ is upregulated by TLR2 stimulation and supports γδ IL-17A production through fatty acid oxidation.