Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates CXCR4 mRNA Expression Levels to Potential Clinical Targets.
Florian KocherAlberto PucciniGerold UntergasserAgnieszka MartowiczKai ZimmerAndreas PircherYasmine BacaJoanne XiuJohannes HaybaeckPiotr TymoszukRichard M GoldbergAngelica PetrilloAnthony Frank ShieldsMohamed E SalemJohn L MarshallMichael J HallWolfgang Michael KornChadi NabhanFrancesca BattaglinHeinz-Josef LenzEmil LouSu Pin ChooChee Keong TohSilvia GasteigerRenate PichlerDominik WolfAndreas SeeberPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
High intratumoral CXCR4 mRNA expression is linked to a T cell- and macrophage-rich PDAC phenotype with high expression of inhibitory immune checkpoints. Thus, our findings might serve as a rationale to investigate CXCR4 as a predictive biomarker in patients with PDAC undergoing immune checkpoint inhibition.