Expression of PRL-3 regulates proliferation and invasion of breast cancer cells in vitro.

Isabel Radke Martin GötteMartin SmollichNinette ScharleLudwig KieselPia Wülfing

Published in: Archives of gynecology and obstetrics (2017)

We conclude that PRL-3 is an important regulatory factor for breast cancer cell proliferation and invasion. Loss of PRL-3 function induces an antimetastatic gene expression profile in breast cancer cells. Due to its role in tumor growth and metastasis, PRL-3 emerges as a new therapeutic target in breast cancer therapy.

Keyphrases

breast cancer cells
cancer therapy
poor prognosis
drug delivery
transcription factor
genome wide
copy number
gene expression
dna methylation
long non coding rna