Prenatal BRCA1 epimutations contribute significantly to triple-negative breast cancer development.
Oleksii NikolaienkoHans P EikesdalElisabet OgnedalBjørnar GiljeSteinar LundgrenEgil S BlixHelge EspelidJürgen GeislerStephanie GeislerEmilius A M JanssenSynnøve YndestadLaura MinsaasBeryl LeirvaagReidun LillestølStian KnappskogPer Eystein LønningPublished in: Genome medicine (2023)
Our findings suggest prenatal BRCA1 epimutations might be the underlying cause of around 20% of TNBC and low-ER expression breast cancers. Such constitutional mosaic BRCA1 methylation likely arise through gender-related mechanisms in utero, independent of Mendelian inheritance.