New 3-Acyl Tetramic Acid Derivatives from the Deep-Sea-Derived Fungus Lecanicillium fusisporum .
Xin-Ya XuYanhui TanChenghai GaoKai LiuZhenzhou TangChunju LuHaiyan LiXiaoyong ZhangYong-Hong LiuPublished in: Marine drugs (2022)
Seven rare C3-C6 reduced 3-acyl tetramic acid derivatives, lecanicilliumins A-G ( 1 - 7 ), along with the known analogue cladosporiumin D ( 8 ), were obtained from the extract of the deep-sea-derived fungus Lecanicillium fusisporum GXIMD00542 within the family Clavipitacae. Their structures were elucidated by extensive spectroscopic data analysis, quantum chemistry calculations and chemical reaction. Compounds 1 , 2 , 5 - 7 exhibited moderate anti-inflammatory activity against NF-κB production using lipopolysaccharide (LPS) induced RAW264.7 cells with EC 50 values range of 18.49-30.19 μM.
Keyphrases
- lps induced
- data analysis
- inflammatory response
- molecular dynamics
- induced apoptosis
- cell cycle arrest
- oxidative stress
- fatty acid
- molecular docking
- density functional theory
- structure activity relationship
- high resolution
- high intensity
- cell death
- endoplasmic reticulum stress
- immune response
- mass spectrometry
- pi k akt
- cell proliferation
- energy transfer
- nuclear factor