Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians.

Liubov ArbeevaMichelle YauBraxton D MitchellRebecca D JacksonKathleen RyanYvonne M GolightlyMarian T HannanAmanda NelsonJoanne M JordanMarc C Hochberg

Published in: Journal of foot and ankle research (2020)

In this report of the largest GWAS of hallux valgus to date, we identified a novel genome-wide significant locus for hallux valgus. Additional replication and functional follow-up will be needed to determine the functional role of this locus in hallux valgus biology.

Keyphrases

genome wide
systematic review
dna methylation
genome wide association study
copy number
randomized controlled trial
case control