Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid-induced DNA damage.
Jeffrey MolendijkCathryn M KolkaHenry CairnsSandra BrosdaAhmed MohamedAlok K ShahIan S BrownMark P HodsonThomas HennessyGuanghao LiuThomas StollRenee S RichardsMichael GartsideKalpana PatelNicholas James ClemonsWayne A PhillipsAndrew P BarbourJohan A WesterhuisMichelle M HillPublished in: Clinical and translational medicine (2022)
Integrated multiomics revealed sphingolipid and phospholipid metabolism rewiring during EAC development. FADS2 inhibition and reduction of the high polyunsaturated lipids effectively protected EAC cells from bile acid-induced DNA damage in vitro, potentially through reduced lipid peroxidation.