Dual-Hormone Closed-Loop System Using a Liquid Stable Glucagon Formulation Versus Insulin-Only Closed-Loop System Compared With a Predictive Low Glucose Suspend System: An Open-Label, Outpatient, Single-Center, Crossover, Randomized Controlled Trial.
Leah M WilsonPeter G JacobsKatrina L RamseyNavid ResalatRavi ReddyDeborah BraniganJoseph LeitschuhVirginia GaboFlorian GuillotBrian SenfJoseph El YoussefIsabelle Isa Kristin SteineckNichole S TylerJessica R CastlePublished in: Diabetes care (2020)
The glucagon formulation demonstrated feasibility in a closed-loop system. The DH system reduced hypoglycemia during and after exercise, with some increase in hyperglycemia.
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