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CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing.

Peng ShenTaoyue YangQun ChenHao YuanPengfei WuBaobao CaiLingdong MengXumin HuangJiaye LiuYihan ZhangWeikang HuYi MiaoZipeng LuKui-Rong Jiang
Published in: Molecular cancer (2021)
Our findings reveal that circNEIL3 facilitates the proliferation and metastasis of PDAC through the circNEIL3/miR-432-5p/ADAR1/GLI1/cell cycle and EMT axis and that its expression is regulated by ADAR1 through a negative feedback loop. Therefore, circNEIL3 may serve as a prognostic marker and a therapeutic target for PDAC.
Keyphrases
  • cell cycle
  • transcription factor
  • cell proliferation
  • crispr cas
  • poor prognosis
  • epithelial mesenchymal transition
  • signaling pathway
  • genome wide
  • single cell
  • binding protein
  • gene expression