Molecular characterization of the circadian clock in paediatric leukaemia patients: a prospective study protocol.
Marius LudwigAlireza BastiMüge YalçinJohannes H SchulteAngela RelógioPublished in: BMC pediatrics (2023)
To the best of our knowledge this is the first study aiming to characterize the circadian clock in a cohort of paediatric patients with acute leukaemia. In the future we hope to contribute to uncovering further vulnerabilities of cancers associated with the molecular circadian clock and in particular adjust chemotherapy accordingly, leading to more targeted toxicity, and hence decreased systemic toxicities.
Keyphrases
- end stage renal disease
- intensive care unit
- emergency department
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- randomized controlled trial
- peritoneal dialysis
- prognostic factors
- squamous cell carcinoma
- cancer therapy
- locally advanced
- patient reported outcomes
- radiation therapy
- drug delivery
- oxide nanoparticles