Risk of ischemic stroke and the use of individual non-steroidal anti-inflammatory drugs: A multi-country European database study within the SOS Project.
Cristina RebordosaBianca KollhorstCristina Varas LorenzoAndrea ArfèRon HeringsSilvia LucchiSilvana RomioRené SchadeMartijn J SchuemieHuub StraatmanVera ValkhoffMarco VillaMiriam SturkenboomEdeltraut GarbePublished in: PloS one (2018)
Risk of IS differs between individual NSAIDs and appears to be higher in patients with a prior history of IS or transient ischemic attack (TIA), in younger or male patients. Co-medication with aspirin, other antiplatelets or anticoagulants might mitigate this risk. The small to moderate observed risk increase (by 13-46%) associated with NSAIDs use represents a public health concern due to widespread NSAID usage.
Keyphrases
- anti inflammatory drugs
- public health
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- cerebral ischemia
- cardiovascular disease
- high intensity
- quality improvement
- atrial fibrillation
- coronary artery disease
- type diabetes
- patient reported outcomes
- oxidative stress
- patient reported
- cardiovascular events
- blood brain barrier
- subarachnoid hemorrhage
- global health