A Novel Allele-Specific PCR Protocol for the Detection of the HLA-C*03:02 Allele, a Pharmacogenetic Marker, in Vietnamese Kinh People.
Tran Thu Ha PhamTran Quang BinhChonlaphat SukasemVan Dinh NguyenChi Hieu ChuThi Quynh Nga DoNgoc Phuong Mai TranHuong Thanh PhungPublished in: The application of clinical genetics (2021)
A novel AS-PCR protocol with a sensitivity of 100% for the detection of the HLA-C*03:02 allele was established. The protocol can be used for personalized treatment with allopurinol in order to minimize the risk of SCARs in Vietnamese people as well as in other Asian populations with similar genetic characteristics.