Target residence of Cas9-sgRNA influences DNA double-strand break repair pathway choices in CRISPR/Cas9 genome editing.
Si-Cheng LiuYi-Li FengXiu-Na SunRuo-Dan ChenQian LiuJing-Jing XiaoJin-Na ZhangZhi-Cheng HuangJi-Feng XiangGuo-Qiao ChenYi YangChao LouHao-Dan LiZhen CaiShi-Ming XuHui LinAn-Yong XiePublished in: Genome biology (2022)
Target residence of Cas9-sgRNA modulates DSB repair pathway choices likely through varying dissociation of Cas9-sgRNA from cleaved DNA, thus widening on-target and off-target mutational spectra in CRISPR/Cas9 genome editing.