Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations.
Kai WangXian ShiZiwei ZhuXingjie HaoLiangkai ChenShanshan ChengRoger S Y FooChaolong WangPublished in: Genome medicine (2022)
We confirmed the causal effects of 10 cardiometabolic traits on CAD and identified causal risk effects of RBC, hemoglobin, hematocrit, and UA independent of traditional cardiometabolic factors. We found no causal effects for 23 clinical factors, despite their reported epidemiological associations. Our findings suggest the physiology of red blood cells and the level of UA as potential intervention targets for the prevention of CAD.
Keyphrases
- coronary artery disease
- red blood cell
- randomized controlled trial
- percutaneous coronary intervention
- coronary artery bypass grafting
- cardiovascular events
- type diabetes
- genome wide
- cardiovascular disease
- gene expression
- acute coronary syndrome
- dna methylation
- climate change
- genetic diversity
- aortic stenosis
- ejection fraction