Adaptation of the transcriptional response to resistance exercise over 4 weeks of daily training.
Mark R ViggarsHazel SutherlandHermann LanmüllerMartin SchmollManfred BijakJonathan C JarvisPublished in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2022)
We present the time course of change in the muscle transcriptome 1 h after the last exercise bout of a daily resistance training program lasting 2, 10, 20, or 30 days. Daily exercise in rat tibialis anterior muscles (5 sets of 10 repetitions over 20 min) induced progressive muscle growth that approached a new stable state after 30 days. The acute transcriptional response changed along with progressive adaptation of the muscle phenotype. For example, expression of type 2B myosin was silenced. Time courses recently synthesized from human exercise studies do not demonstrate so clearly the interplay between the acute exercise response and the longer-term consequences of repeated exercise. We highlight classes of transcripts and transcription factors whose expression increases during the growth phase and declines again as the muscle adapts to a new daily pattern of activity and reduces its rate of growth. Myc appears to play a central role.
Keyphrases
- physical activity
- high intensity
- transcription factor
- skeletal muscle
- resistance training
- gene expression
- poor prognosis
- multiple sclerosis
- liver failure
- drug induced
- binding protein
- oxidative stress
- respiratory failure
- dna methylation
- single cell
- genome wide
- rna seq
- intensive care unit
- diabetic rats
- extracorporeal membrane oxygenation
- virtual reality