Activity-induced gene expression in the human brain.

Snehajyoti ChatterjeeBrian J ParkYann Vanrobeys Shane A Heiney Ariane E Rhone Kirill V Nourski Lucy Langmack Utsav Mukherjee Christopher K Kovach Zsuzsanna Kocsis Yukiko Kikuchi Christopher I Petkov Marco M Hefti Ethan Bahl Jacob J Michaelson Hiroto Kawasaki Hiroyuki OyaMatthew A HowardThomas K Nickl-Jockschat Li-Chun Lin Ted Abel

Published in: bioRxiv : the preprint server for biology (2023)

Electrical stimulation of the human cortex allows the identification of an activity-dependent gene expression signature.Neurons and microglia in the human brain exhibit distinct transcriptional signatures following electrical stimulation.Single nuclear chromatin accessibility studies reveal cell-type-specific epigenomic changes and specific transcription factor motifs in microglia.

Keyphrases

gene expression
transcription factor
dna methylation
genome wide
spinal cord injury
endothelial cells
inflammatory response
neuropathic pain
high glucose
spinal cord
diabetic rats
dna damage
induced pluripotent stem cells
case control
dna binding
pluripotent stem cells
heat shock protein