Rutaecarpin reduces lipids by DGKθ-dependent activation of PPARα.
Di WuJiheng WangYongxing ChangShiyu ZhangJinfeng LiangJunli ZhaoPeiyan YangQinwen MaoHaibin XiaPublished in: Obesity (Silver Spring, Md.) (2022)
Rutaecarpin is effective in reducing lipid accumulation, and the development of a high-throughput screening platform based on a reporter knock-in cell line may facilitate the discovery of effective drugs for lipid metabolic disorders based on the DGKθ target.