The comparison of pegylated liposomal doxorubicin and beta-carotene effects on JAR and JEG-3 choriocarcinoma human cell culture models
Seyit Ahmet ErolGörker SelMehmet Ibrahim HarmaMüge Harmaİshak Özel TekinPublished in: Journal of the Turkish German Gynecological Association (2020)
To our knowledge, this is the first investigation of the effectiveness of PLD, beta-carotene, and PLD + beta-carotene combination therapy in two different CC cell lines. PLD is a promising chemotherapeutic drug, and beta-carotene can be used as a novel non-chemotherapeutic agent for treatment of CC. Based on the results of this study, vitamin A supplementation may have promise as a preventive measure. However, these data need support from animal experiments and clinical trials.
Keyphrases
- combination therapy
- clinical trial
- endothelial cells
- randomized controlled trial
- healthcare
- big data
- systematic review
- drug delivery
- electronic health record
- emergency department
- machine learning
- study protocol
- open label
- double blind
- replacement therapy
- adverse drug
- data analysis
- recombinant human
- clinical evaluation