[Immunohistochemical study of Ki-67, p53 and Notch1 expressions in prostate cancer of different grades].

G Yu Kudryavtsev L V Kudryavtseva Liudmila M Mikhaleva N A Solovieva Igor I Babichenko

Published in: Arkhiv patologii (2020)

Notch1 expression in conjunction with the low proliferative activity of cells and the absence of p53 (Y5) protein may suggest that the mechanism of apoptosis is preserved in tumor cells, which expands indications for medical treatment of prostate cancer.

Keyphrases

prostate cancer
cell cycle arrest
radical prostatectomy
induced apoptosis
endoplasmic reticulum stress
cell death
cell proliferation
oxidative stress
poor prognosis
healthcare
binding protein
pi k akt
protein protein
neoadjuvant chemotherapy
small molecule
rectal cancer