Comprehensive behavioral analysis of tryptophan 2,3-dioxygenase (Tdo2) knockout mice.

Satoko Hattori Keizo TakaoHiroshi FunakoshiTsuyoshi Miyakawa

Published in: Neuropsychopharmacology reports (2018)

He lack of clear phenotypes in Tdo2KO mice in this study might be due to the absence of stress and inflammatory conditions, which could induce expression of Tdo2 mRNA. Further studies are necessary to elucidate the roles of Tdo2 in behavioral phenotypes related to psychiatric disorders.

Keyphrases

poor prognosis
binding protein
oxidative stress
type diabetes
metabolic syndrome
stress induced
case control
long non coding rna