Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1α expression in parasympathetic versus sympathetic paragangliomas.
Cristóbal Bernardo-CastiñeiraInés Sáenz-de-Santa-MaríaNuria ValdésAurora AstudilloMilagros BalbínAna S PitiotPaula Jiménez-FonsecaBartolomé ScolaIsabel TenaMaría-José Molina-GarridoMaría-Agustina SevillaElena BeristeinLluís ForgaCarles VillabonaJosep OriolaIrene HalperinCarlos SuarezMaría-Dolores ChiaraPublished in: Head & neck (2018)
As in PCCs/PGLs, SDHB immunohistochemistry in HNPGLs is a valuable method for identification of candidates for SDHx-genetic testing. On the contrary, although SDHx mutations may favor HIF-1α stabilization in HNPGLs, this is not a clinically useful biomarker.