Alteration of PPAR-GAMMA (PPARG; PPARγ) and PTEN gene expression in acute myeloid leukemia patients and the promising anticancer effects of PPARγ stimulation using pioglitazone on AML cells.
Shadi EsmaeiliSina SalariVahid KavehSeyed H GhaffariSoroush SadeghiPublished in: Molecular genetics & genomic medicine (2021)
The results of the present study shed more light on the importance of PPARγ and its stimulation in the therapeutic strategies of AML.
Keyphrases
- gene expression
- insulin resistance
- acute myeloid leukemia
- end stage renal disease
- ejection fraction
- induced apoptosis
- fatty acid
- newly diagnosed
- chronic kidney disease
- dna methylation
- cell proliferation
- prognostic factors
- peritoneal dialysis
- allogeneic hematopoietic stem cell transplantation
- cell cycle arrest
- metabolic syndrome
- acute lymphoblastic leukemia