Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx.
Nicole R GayMichael GloudemansMargaret L AntonioNathan S AbellBrunilda BalliuYoSon ParkAlicia R MartinShaila MusharoffAbhiram S RaoFrançois AguetAlvaro N BarbeiraRodrigo BonazzolaFarhad Hormozdiarinull nullKristin G ArdlieChristopher D BrownHae Kyung ImTuuli LappalainenXiaoquan WenStephen B MontgomeryPublished in: Genome biology (2020)
We provide a local ancestry map for admixed individuals in the GTEx v8 release and describe the impact of ancestry and admixture on gene expression, eQTLs, and GWAS colocalization. While the majority of the results are concordant between local and global ancestry-based adjustments, we identify distinct advantages and disadvantages to each approach.