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The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice.

Montserrat A de la Rosa RodriguezGo SugaharaGuido J E J HooiveldYuji IshidaChise TatenoSander Kersten
Published in: BMC genomics (2018)
The results support the major role of PPARα in regulating hepatic lipid metabolism, and underscore the more modest effect of PPARα activation on gene regulation in human liver compared to mouse liver. The data suggest that PPARα may have a suppressive effect on DNA synthesis in human liver, and a stimulatory effect on interferon/cytokine signalling.
Keyphrases
  • insulin resistance
  • fatty acid
  • gene expression
  • dendritic cells
  • electronic health record
  • type diabetes
  • genome wide
  • metabolic syndrome
  • skeletal muscle
  • immune response
  • circulating tumor
  • dna methylation