Clinical Utility of Plasma Cell-Free DNA in Adult Patients with Newly Diagnosed Glioblastoma: A Pilot Prospective Study.
Stephen J BagleyS Ali NabavizadehJazmine J MaysJacob E TillJeffrey B WareScott LevyWhitney SarchiaponeJasmin HussainTimothy PriorSamantha GuiryTheresa ChristensenStephanie S YeeMac Lean P NasrallahJennifer J D MorrissetteZev A BinderDonald M O'RourkeAndrew J CucchiaraSteven BremArati S DesaiErica L CarpenterPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Plasma cfDNA may be an effective prognostic tool and surrogate of tumor burden in newly diagnosed GBM. Detection of somatic alterations in plasma is feasible when samples are obtained prior to initial surgical resection.