Succession of physiological stages hallmarks the transcriptomic response of the fungus Aspergillus niger to lignocellulose.
Jolanda M van MunsterPaul DalyMartin J BlytheRoger IbbettMatt KokolskiSanyasi GaddipatiErika LindquistVasanth R SinganKerrie W BarryAnna LipzenChew Yee NganChristopher J PetzoldLeanne Jade G ChanMikko ArvasRoxane RauloSteven T PullanStéphane DelmasIgor V GrigorievGregory A TuckerBlake A SimmonsDavid B ArcherPublished in: Biotechnology for biofuels (2020)
In this study, which includes the first transcriptional response of Aspergilli to Miscanthus, we highlighted that life time as well as substrate composition and structure (via variations in pretreatment and feedstock) influence the fungal responses to lignocellulose. We also demonstrated that the fungal response contains physiological stages that are conserved across substrates and are typically found outside of the conditions with high CAZyme expression, as exemplified by the stages that are dominated by lipid and secondary metabolism.