Molecular mechanism of XB130 adaptor protein mediates trastuzumab resistance in gastric cancer.

Shengnan YangBinbin WangJiaqi LiaoZiyang HongXuxian ZhongSuling ChenZiqing WuXingyu ZhangQiang Zuo

Published in: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico (2022)

In HER2 + GC, XB130 contributes to trastuzumab resistance by stimulating the PI3K/AKT signaling pathway through binding to PI3K p85α under the mediation of SRC kinase and regulating PTEN gene transcription, and in turn forming a positive feedback loop between SRC-XB130-PTEN.

Keyphrases

tyrosine kinase
pi k akt
epidermal growth factor receptor
signaling pathway
cell proliferation
transcription factor
copy number
epithelial mesenchymal transition
genome wide
social support
gene expression
binding protein
depressive symptoms
oxidative stress
high resolution
gas chromatography