Overexpression of long noncoding RNA LINC00638 inhibits inflammation and oxidative stress in rheumatoid arthritis fibroblast-like synoviocytes by regulating the Nrf2/HO-1 pathway.
Yanqiu SunJian LiuJianting WenDan HuangQin ZhouXianheng ZhangXiang DingXiaolu ChenPublished in: Immunity, inflammation and disease (2022)
LINC00638 was found to be expressed at low levels in RA patients and was associated with immune inflammation, oxidative stress, and disease activity. Overexpression of LINC00638 can reduce the proliferation as well as migration of RA-FLS, and activate the Nrf2/HO-1 pathway to inhibit the inflammation and oxidative stress.
Keyphrases
- oxidative stress
- long noncoding rna
- disease activity
- rheumatoid arthritis
- systemic lupus erythematosus
- cell proliferation
- ankylosing spondylitis
- rheumatoid arthritis patients
- diabetic rats
- dna damage
- ischemia reperfusion injury
- long non coding rna
- induced apoptosis
- end stage renal disease
- juvenile idiopathic arthritis
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- transcription factor
- prognostic factors
- chronic kidney disease
- interstitial lung disease
- signaling pathway
- heat shock
- pi k akt
- systemic sclerosis
- idiopathic pulmonary fibrosis
- heat stress