Practical considerations for the use of direct oral anticoagulants in oncology patients.
Arianne DuongSarah SingCathy TaketaAbby MiskeEve SegalDavid GarciaPublished in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2019)
Oncology patients are at a high risk of experiencing venous thromboembolism. Historically, venous thromboembolisms in cancer patients have been managed with low-molecular-weight heparin on the basis of the CLOT trial published in 2003. However, recent prospective data provide evidence for safe and effective direct oral anticoagulant use in this population. The purpose of this review article is to evaluate the current body of literature surrounding direct oral anticoagulant use in the oncology population and to highlight key practical considerations when prescribing these agents for patients with cancer.
Keyphrases
- venous thromboembolism
- direct oral anticoagulants
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- palliative care
- atrial fibrillation
- primary care
- clinical trial
- peritoneal dialysis
- randomized controlled trial
- study protocol
- patient reported outcomes
- electronic health record
- machine learning
- deep learning
- phase iii
- growth factor