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Regulating Pathways of Bacillus pumilus Adamalysin-like Metalloendopeptidase Expression.

Natalia L RudakovaAlbina R SabirovaDamir I KhasanovIuliia V DanilovaMargarita R Sharipova
Published in: International journal of molecular sciences (2023)
The minor secreted proteinase of B. pumilus 3-19 MprBp classified as the unique bacillary adamalysin-like enzyme of the metzincin clan. The functional role of this metalloproteinase in the bacilli cells is not clear. Analysis of the regulatory region of the mprBp gene showed the presence of potential binding sites to the transcription regulatory factors Spo0A (sporulation) and DegU (biodegradation). The study of mprBp activity in mutant strains of B. subtilis defective in regulatory proteins of the Spo- and Deg-systems showed that the mprBp gene is partially controlled by the Deg-system of signal transduction and independent from the Spo-system.
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