Apolipoprotein A-IV restrains fat accumulation in skeletal and myocardial muscles by inhibiting lipogenesis and activating PI3K-AKT signalling.

Wenqian Zhang Xiao-Huan LiuJin-Ting ZhouCheng ChengJing XuJun YuXiaoming Li

Published in: Archives of physiology and biochemistry (2023)

We find that ApoA-IV reduces fat accumulation by suppressing lipogenesis and improves glucose uptake in SKM and the myocardium by regulating the PI3K-AKT pathway.

Keyphrases

signaling pathway
pi k akt
adipose tissue
cell cycle arrest
cell proliferation
high fat diet induced
fatty acid
left ventricular
blood glucose
insulin resistance
heart failure
skeletal muscle
metabolic syndrome
atrial fibrillation
blood pressure