Developmentally regulated GTP-binding protein 2 levels in prostate cancer cell lines impact docetaxel-induced apoptosis.
Seong Cheol KimWon Hyeok LeeSong Hee KimAbdumadjidov Alisher AbdulkhayevichJeong Woo ParkYoung Min KimKyung Hyun MoonSang Hun LeeSungchan ParkPublished in: Investigative and clinical urology (2022)
In prostate cancer cells, DRG2 regulates G2/M arrest after docetaxel treatment. In prostate cancer cells with DRG2 knockdown, apoptosis increases without G2/M arrest in response to docetaxel treatment. These results show that inhibition of DRG2 expression can be useful to enhance docetaxel-induced apoptosis despite low-dose administration in castration-resistant prostate cancer.