Impact of Isoniazid Preventive Therapy on Tuberculosis incidence among people living with HIV: A secondary data analysis using Inverse Probability Weighting of individuals attending HIV care and treatment clinics in Tanzania.
Werner M MaokolaBernard J NgowiMichael J MahandeJim ToddMasanja RobertSia E MsuyaPublished in: PloS one (2021)
IPT reduced TB incidence by 52% in PLHIV attending routine CTC in Tanzania. IPTW adjusted the groups for imbalances in the covariates associated with receiving IPT to achieve comparable groups of IPT and non-IPT. This study has added evidence on the effectiveness of IPT in routine clinical settings and on the use of IPTW to determine impact of interventions in observational studies.
Keyphrases
- mycobacterium tuberculosis
- risk factors
- clinical practice
- randomized controlled trial
- systematic review
- primary care
- tertiary care
- physical activity
- pulmonary tuberculosis
- emergency department
- stem cells
- electronic health record
- machine learning
- mesenchymal stem cells
- hiv aids
- combination therapy
- replacement therapy
- artificial intelligence
- data analysis
- circulating tumor