Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis.
Sofie Louise RygårdEthan ButlerAnders GranholmMorten Hylander MøllerJeremy CohenSimon R FinferAnders PernerJohn MyburghBalasubramanian VenkateshAnthony DelaneyPublished in: Intensive care medicine (2018)
In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaffected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced. PROSPERO registration no. CRD42017084037.
Keyphrases
- septic shock
- mechanical ventilation
- low dose
- intensive care unit
- acute respiratory distress syndrome
- high dose
- respiratory failure
- preterm infants
- clinical trial
- study protocol
- cardiovascular events
- phase iii
- extracorporeal membrane oxygenation
- randomized controlled trial
- risk factors
- type diabetes
- coronary artery disease
- preterm birth